DNA Lounge is at 375 Eleventh Street, between Folsom and Harrison (near Harrison). Here's a map.
From the South Bay:
Take 101 North to the 9th Street / Civic Center exit. Take 9th Street, and turn left onto Harrison, then right onto 11th.
From the East Bay:
From the Bay Bridge, take I-80 West to the 9th Street / Civic Center exit. Keep right at the fork in the ramp. Turn left onto Harrison, then right onto 11th.
By Public Transit:
The nearest BART stations are at 16th and Mission and Civic Center (Market and Hyde), both about 3/4ths of a mile away. There are bus stops at 11th and Harrison (right outside the club), and at Market and Van Ness (four blocks away).
People often ask us what hotels we recommend. The nearest hotel is the Best Western Civic Center Motor Inn, two blocks away at 364 Ninth at Harrison. We also like The Phoenix Hotel, about a mile away at 601 Eddy at Larkin.
Ample public parking is available at the Costco parking lot across the street from DNA Lounge, at the corner of 11th and Harrison. The parking lot entrance is on 11th. You can also find free street parking, but beware of the street cleaning signs.